Grigory VEINBERG
Dr. Grigory VEINBERG Dr.habil. chem. Phone: +371 67555946 |
Interests:
- Bioorganic Chemistry
- Penicillins and Cephalosporins
- ß-Lactamase and Elastase Inhibitors, Citotoxic Agents
- Quantitative Structure Activity Relationship
Research interests include Quantitative Structure Activity Relationship determination for penicillin and cephalosporin derivatives with Elastase or ß-Lactamase inhibitory properties and nitric oxide generating properties.
Languages: English, Latvian, Russian.
Education:
- Riga Politechnical Institute (Faculty of Chemistry), 1964
- Dr. chem. (Candidate of Science in former USSR, Ph.D. in Western countries), Latvian Academy of Sciences, 1971
- Dr. habil. chem. (Doctor of Science in former USSR), Latvian Academy of Sciences, 1987.
Experience:
Latvian Institute of Organic Synthesis -
- Junior Researcher, 1970-1974
- Senior Researcher, 1975-1983
- Leading Researcher, 1984-
Honours and Awards:
- Corresponding Member, Latvian Academy of Sciences, 2000
- The Latvian Academy of Sciences G.Vanags Prize, 2009
- The D.H.Grindel Medal (Company "Grindex", Latvia), 2000
- The S.Hiller Medal (Latvian Institute of Organic Synthesis), 1996
- The Latvian Academy of Sciences Presidium Third Award, 1985
- The Latvian Academy of Sciences Presidium First Award, 1974
Professional Activities and Memberships:
- Member, Latvian Council of Science Expert Committee for Chemistry, 1993-
- Member of the Scientific Council, Latvian Institute of Organic Synthesis, 1999-
- Head of the Scientific Council, Latvian Institute of Organic Synthesis, 2005 -
Courses:
- Structure Activity Relationships for Organic Substances, Riga Technical University, 1989-
- ß- Lactam Antibiotics, Riga Technical University, 1989-
Recent/Representative Publications:
- G. Veinberg, I. Shestakova, L. Petrulanis, N. Grigan, D. Musel, D. Zeile, I. Kanepe, I. Domrachova, I. Kalvinsh, A. Strakovs, E. Lukevics. Synthesis and Evaluation of Dual Action Cephalosporins as Elastase Inhibitors. - Bioorganic & Medical Chemistry Letters, 1997, vol. 26, N 7, 843.
- G.Veinberg, I.Shestakova, N.Grigan, D.Musel, I.Kanepe, I.Domrachova, I.Grigoryeva, O.Zharkova, I.Turovskis, I.Kalvinsh, A.Strakovs, E.Lukevics. New biological properties of tert-butyl cepalosporanate sulfones. - Eur. J. Med. Chem., 1998, vol. 33, N 10, pp. 755-762.
- G.A.Veinberg, R.Bokaldere, K.Dikovskaya, M.Vorona, D.Musel, H.Kazhoka, I.Turovsky, I.Shestakova, I.Kanepe, I.Domracheva, E.Lukevics. Synthesis of penicillin derivatives and study of their cytotoxic properties. - Khim. Geterotsikl. Soedin., 1998, N 11, pp. 1494-1503.
- P.S.Nys, V.B.Kurochkina, A.V.Skliarenko, G.A.Veinberg. b-Lactams. Structure and biological activity relationship. - Antibiot. Khimioter., 2000, vol. 45, N 11, pp. 36-42 (in Russian).
- G. Veinberg , M. Vorona, I. Shestakova, I. Kanepe, E. Lukevics. Design of b-lactams with mechanism based nonantibacterial activities. - Cur. Med. Chem., 2003, vol. 10, 1741-1757.
- G. Veinberg, R. Bokaldere, M. Vorona, I. Kanepe, I. Shestakova, E. Lukevics.
The synthesis of cytotoxic 1,3,4-trisubstituted azetidinones-2. - Chem. Heterocycl. Chem., 2003, N 5, pp. 680-687.- G. Veinberg, I. Shestakova, M. Vorona, I. Kanepe, I.Domrachova, E. Lukevics. Doxorubicin prodrug on the base of tert-butyl cephalosporanate sulfones. - Bioorg. Med. Chem. Letters, 2004, vol. 14, No 1, 147-150.
- G. Veinberg, I. Shestakova, M. Vorona, I. Kanepe, E. Lukevics. Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones. - Bioorg. Med. Chem. Letters, 2004, vol. 14, No 4, 1007-1010.
- J.Melnik, M.Vorona, G.Veinberg, J.Popelis, L.Ignatovich, E.Lukevics. The synthesis and stereoisomerism of 2-(1-alkoxyimino-2,2,2-trifluoroethyl)-5-trimethylsilylfurans. - Chem. Heterocycl. Comp., 2005, N 6, pp.834-838.
- M.Vorona, G.Veinberg, I.Shestakova, et al. Synthesis and anticancer properties of 7alpha-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters. - Chem.Heterocycl. Comp. (Engl. Ed.). 2007, vol. 43, N 2, pp. 207-219.
- M.Dambrova, L.Zvejniece, E.Liepinsh, H.Cirule, O.Zharkova, G.Veinberg, I.Kalvinsh. Comparative pharmacological activity of optical isomers of phenibut. - Eur. J. Pharm., 2008, vol. 583, pp. 128-134.
- M.Vorona, I.Potorochina, G.Veinberg, I.Shestakova, I.Kanepe, E. Lukevics. Synthesis and stereoisomerism of derivatives of tert-butyl 7-alkylideneceph-3-em-4-carboxylate. - Chem.Heterocycl. Comp. (Engl. Ed.). 2008, vol. 44, N 4, pp.486-493.
- I.Potorochina, M.Vorona, G.Veinberg, I.Shestakova, I.Kanepe, M.Petrova, E.Liepinsh, E. Lukevics. Synthesis and cytotoxic activity of derivatives of the tert-Butyl ester of 7Z-acethylmethylene-3-methyl-3-cephem-4-carboxylic acid. - Chem.Heterocycl. Comp. (Engl. Ed.). 2009, vol. 45, N 2, pp. 228-244.
Research Projects:
- G.A.Veinbergs (Head of Project). Beta Lactam Containing Antibiotics. Latvian Council of Science (1991-1993).
- G.A.Veinbergs (Head of Project). Investigation of Cephalosporin Analogs. Latvian Council of Science (1994-1996).
- G.A.Veinbergs (Head of Project). Cancer Factors in the Genesis of Tumor Metastasizing and Its Pharmacological Control. Latvian Council of Science (1995-1996).
- G.A.Veinbergs (Head of Project). Dual Action Anti-inflammatory Cephalosporis. Latvian Taiho Fund (1994 -1996).
- G.A.Veinbergs (Head of Project). The Synthesis of Anti-inflammatory and Citotoxic Cephalosporin Analogs. Latvian Council of Science (1997-2000).
- G.A.Veinbergs (Head of Project). The Synthesis of NO Generating ß-Lactam Antibiotics Analogs. Latvian Council of Science (1997-2000).
- G.A.Veinbergs (Head of Project). Cancer Factors in the Genesis of Tumor Metastasing and Its Pharmacological Control. Latvian Council of Science (1997- 2000) .
- G.A.Veinbergs (Head of Project). The Synthesis and Biological Investigation of ß-Lactam Derivatives Acting as Protease Inhibitors. Latvian Council of Science ( 2001 - 2004) .
- G.A.Veinbergs (Head of Project). The Synthesis of NO Generating ß-Lactam Antibiotics Analogs. Latvian Council of Science ( 2002 - 2005) .
- >G.A.Veinbergs (Head of Project). Generation of biochemically induced cytotoxic signal photon emission in monolayer cells. Latvian Council of Science ( 2005 - ) .
- G.A.Veinbergs (Head of Project). Synthesis and biological investigation of anticancer beta-lactam derivatives. Latvian Council of Science (2005 - ) .
Last update 08.11.2009