Lubov IGNATOVICH
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Dr.habil.chem. Lubov IGNATOVICH
Principal scientist
Head of the Laboratory of Organometallic Chemistry
Latvian Institute of Organic Synthesis
21, Aizkraukles str.,
Riga, LV-1006, LatviaPhone: +371 7553355; +371 29590575
e-mail: ign@osi.lv; luba@ignatovica.lv
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Born: 1953 July 8, Rezekne, Latvia
Interests:
- Organometallic (silicon, germanium, tin) chemistry
- Penta- and hexa-coordinated organosilicon and germanium compounds
- Chemistry of heterocycles (furan, thiophene, pyrimidine)
- Synthesis of biologically active compounds
Languages: Russian, Latvian, English
Education:
- University of Latvia (Faculty of Chemistry), 1976
- Dr.chem. (Candidate of Science in former USSR, Ph.D. in Western countries),
Institute of Organic Synthesis, Riga, 1985
Thesis: "Synthesis and transformations of furylgermanes
- Dr.habil.chem., University of Latvia, Riga, 1998
Thesis: Synthesis, structure and biological activity of germyl- and
germaheterocycles
Experience: Latvian Institute of Organic Synthesis
- Scientific coworker, 1971-1976
- Engineer, 1976 -1981
- Junior Researcher, 1982-1985Researcher, 1985-1989
- Senior Researcher (Principal scientist), 1989 - 2009
- Head of the Laboratory of Organometallic Chemistry
Visiting researcher:
- ICIDCA, Habana, Cuba (Dr. Irma Castro-Mendez), 1988
- Cuban University, Habana, Cuba (Prof. Margarita Suaresh), 1989
- Tsukuba University, Tsukuba, Japan (Prof. Wataru Ando), 1990
- Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1991
- Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1992
- RIKEN, Sendai, Japan (Prof. Mitsuo Kira), 1993 -1994
- Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 1997
- Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 2001
Awards:
- The Latvian Academy of Sciences Presidium Award 1992
- Person of the Year Award (Marqui's Who's Who in the World), 2009
- Margus's Who's Who in Science and Engineering 2008 - 2009.
Plenary and invited Lectures:
- IV All-Union Conference on the Chemistry of Nitrogen-contaning Heterocyclic Compounds
(Novosibirsk, USSR), 1987
- XVII All-Union Conference on the Synthesis and Reactivity of Organic Compounds of Sulfur
(Tbilisi, USSR), 1989
- Tohoku University (Sendai, Japan), 1992
- University of Toulouse (France), 1994
- International Conference on environmental and biological aspects of main-group
organometals (ICEBAMO 94), Bordeaux (France), 1994
- 5th Blue Danube symposium on heterocyclic chemistry (5th BDSHC), Chasta-Papernicka
(Slovak Republic), 1995
- Nippon Soda Company, Odawara (Japan), 1997
- 5th International Conference on environmental and biological aspects of main-group
organometals, Schielleiten (Austria), 2001
- Uppsala University (Uppsala, Sweden), 2004
- 14th International Symposium on Organosilicon Chemistry, Wurzburg, (Germany), 2005
Representative Publications:
- Lukevics E., Gar T.K., Ignatovich L.M., Mironov V.F. Biological activity of
germanium compounds.- Riga: Zinatne,1990.-191p. (in Russian).
- Lukevics E., Ignatovich L. Uracil derivatives of Group 14 elements // Frontiers
of organogermanium, -tin and -lead chemistry / Ed. By E. Lukevics, L.Ignatovich.
Riga: IOS,1993, 331-341.
- Lukevics E., Ignatovich L. Toxicity of organogermanium compounds. The chemistry
of organic germanium, tin and lead compounds / ed. By S. Patai. Chichester: John
Wiley & Sons, 1995, 857-863.
- Belyakov S., Ignatovich L., Lukevics E. Concerning the transannular bond in
silatranes and germatranes: a quantum chemical study // J. Organomet. Chem. , 1999,
577, 205-210.
- Lukevics E., Ignatovich L., Belyakov S. Synthesis and molecular structure of
phenyl and tolylgermatranes // J. Organomet. Chem., 1999, 588, 222-230.
- Kira M., Ishida S., Ichinohe M., Kabuto C., Ignatovich L., Sakurai H. Synthesis
and structure of a stable cyclic dialkylgermylene // Chem. Letters ,1999, 263-264.
- Hashimoto H., Yagihashi Y., Ignatovich L., Kira M. Characterization and
properties of 1,2-Disiladigerma-cyclobutane // Heteroatom Chem., 2001, 12,.398-405.
- Ignatovich L.,
Zarina Dz., Shestakova I., Germane S., Lukevics E. Synthesis and
biological activity of silyl- and germylsubstituted trifluoroacetylfurans // Metal-Based
Drugs, 2002, 8, 211-214.
- Lukevics E., Ignatovich L. Biological activity of organogermanium compounds. The
Chemistry of Organic Germanium, Tin and Lead Compounds. Ed. Z.Rappoport, Chichester: John
Wiley & Sons Ltd. 2002, 1651-1683.
- Lukevics E., Ignatovich L, Shulga T., Belyakov S. Synthesis, molecular
structure and biological activity of bromobenzylgermatranes // J. Organomet. Chem.,
2002, 659, 165-171.
- Lukevics E., Ignatovich L., Shestakova I.Synthesis, psychotropic and anticancer
activity of
2,2-dimethyl-5-[5-trialkylgermyl-(silyl)-2-hetarylidene]-1,3-dioxane-4,6-diones
and their analogues //Appl. Organomet. Chem., 2003, 17, 898-905.
- Lukevics E., Ignatovich L. Biological Activity of Organosilicon Compounds.
Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine.
Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(5), 83-107.
- Lukevics E., Ignatovich L. Biological Activity of Organogermanium Compounds.
Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine.
Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(15), 279-295.
- Ignatovich L.,
Zarina D., Shestakova I., Germane S., Lukevics E. Synthesis and
biological activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes.
Organosilicon Chemistry VI: Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA.
2005, From Molecules to Materials. Vol.1, Chapter 1, 563-568.
- Lukevics E., Ignatovich L., Sleiksha I., Shestakova I., Domrachova I., Popelis J.
Synthesis and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes and
their thiosemicarbazones. //Appl. Organomet. Chem., 2005, 19, 1109-1113.
- Ignatovich L.,
Popelis J., Lukevics E. Synthesis and NMR spectra of dyaryl- and
dihetarylsilacycloalkanes. Organosilicon Chemistry VI: [Ed. by N.Auner and J.Weis.
Wiley-VCH Verlag GmbH&Co.KGaA]. 2005, From Molecules to Materials. Vol.1, Chapter 1,
559-562.
- Lukevics E., Ignatovich L., Sleiksha I., Muravenko V., Shestakova I., Belyakov
S., Popelis J. Synthesis, structure and cytotoxic activity of
2-acetyl-5-trimethylsilylthiophene(furan) and their oximes. //Appl. Organomet. Chem., 2006,
20, 454-458.
- Ignatovich L.,
Muravenko V., Grinberga S., Lukevics E. Novel reactions to form an
Si-O-Ge group. // Chem. Heterocycl. Comp. , (Engl. Ed.). 2006, 42, 268-271.
- Lukevics E., Ignatovich L., Sleiksha I., Romanov V., Grinberga S., Popelis J.,
Shestakova I. New synthetic way to silicon and germanium containing 2-acetylfurans and
thiophenes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2007, 43, 145-150.
- Lukevics E., Ignatovich L., Belyakov S. Disordering in crystal structures of
thienylgermatranes.// Chem. Heterocycl. Comp. (Engl. Ed.). 2007, 43, 243-249.
Soualami S., Ignatovich L., Lukevics E., Ourari A., Jouikov V. Electrochemical
oxidation of benzylgermatranes.// J. Organomet. Chem., 2008, 693, 1346-1352.
Lukevics E., Ignatovich L., Shul'ga T., Belyakov S. Synthesis and crystal
structure of 1-(4-fluorophenyl)- and 1-(4-dimethylamino)phenylgermatranes. // Chem.Heterocycl.
Comp. (Engl. Ed.)., 2008, 44, 615-620.
Ignatovich L., Muravenko V., Shestakova I.,Domracheva I., Popelis J., Lukevics
E. Synthesis and cytotoxic activity of new
2-[(3-aminopropyl)dimethylsilyl]-5-triethylsilylfurans. //Appl. Organomet. Chem., 2010,
24(3), 158 - 161.
Ignatovich L., Romanovs V., Shestakova I.,Domracheva I., Popelis J.,
Lukevics E. Synthesis and biological activity of new
2-[(3-aminopropyl)dimethylsilyl]-5-trialkylgermylfurans. //Khim. Geterocikl. Soed., 2009,
12, 1792-1799.
Lukevics E., Abele E., Ignatovich L. Biologically Active Silacyclanes. //
In: Advances in Heterocyclic Chemistry, 2010, Vol. 99, 107-141.
Soualmi
S., Ignatovich L., Jouikov V. Cation radicals of organogermatranes.// Appl. Organomet.
Chem. 2010, 24(12), 865-87.
Ignatovich
L.,
Romanovs V., Spura J., Popelis J., Domracheva I., Shestakova I. Synthesis and antitumor
activity of 3-[(Methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines. //Chem.Heterocycl.Comp.
(Engl. Ed.), 2011, 47(12), 1502-1508.
Ignatovich
L., Muravenko V., Spura J., Popelis J., Domrachova I., Shestakova I. Synthesis,
Structure and Cytotoxicity of New 2-[(3-Aminopropyl)dimethylsilyl]-5-furfural
Diethylacetals and 2-[(3-Aminopropyl)-dimethylsilyl]-5-phenylfurans. //Appl. Organomet.Chem., 2013, 27(7), 406-411.
Ignatovich
L., Starkova O., Romanovs V., Sleiksha I., Shestakova I., Popelis J., Lukevics E.
Novel Trialkylsilyl(germyl)-substituted Thienyl- and Furylbenzimidazoles and their
N-Substituted Derivatives Synthesis, Structure and Cytotoxic activity. //Comptes Rendus Chimie, 2013, 16(6), 521-627.
Ignatovich L., Jouikov V. Organogermatranes and their cation radicals by EPR-spectroelectrochemistry and ab initio calculations. //J. Organomet. Chem. 2014, 751, 546-554. http://dx.doi.org/10.1016/j.jorganchem.2013.08.007
Ignatovich L., Romanovs V., Muravenko V., Sleiksha I., Popelis J., Shestakova I. Synthesis and Cytotoxic Activity of 1-{3-[1-(5-Organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and Some Trimethylgermyl Analogues. //Chem.-Eur. J. 2014, 20(40), 12786-12788.
Ryabova V., Ignatovich L. Thiophene Substitution Chemistry. /DOI 10.1007/7081_2014_134/. Topics in Heterocyclic Chemistry 2015, Ed. John A Joule, Springer, Switzerland, Vol.39, 43-108.
Ignatovich L., Spura J., Muravenko V., Beďakovs S., Popelis J., Shestakova I., Domrachova I, Gulbe A., Rudevica Z., Leonchik A. Synthesis, structure and biological activity of new 6,6-dimethyl-2-oxo-4-{2-[5-organylsilyl(germyl)]furan(thiophen)-2-yl}vinyl-5,6-dihydro-2H-pyran-3-carbonitriles. //Appl. Organomet. Chem. 2015, 29(11), 756-763.
Research Projects:
- L. Ignatovich (Head of Project). Unsaturated Heterocyclic Carbonyl Compounds as
Antitumor Agents. Latvian Taiho Foundation (1997 -1999).
- L. Ignatovich (Head of Project). Five Coordinated organogermanium Compounds as
Psychotropic and Anticancer Agents. Latvian Taiho Foundation (1999 -2001).
- L. Ignatovich (Head of Project). Diaphorase Activity Regulators: Role in Cancer
Chemotherapy. Latvian Taiho Foundation (2001 -2003).
- L. Ignatovich (Head of Project). Metal Complexes of Silyl and Germyl Substituted Oximes
and Thiosemicarbazones as Antitumour Agents Inhibiting Topoisomerase II. Latvian Taiho
Foundation (2003 -2005).
- L. Ignatovich (Head of Project).Carbofunctional Silylheterocycles. Latvian
Council of Science (2010 - 2012).
- L. Ignatovich (Head of Project).Organic derivatives of hypercoordinate germanium and
germyl(silyl)-heterocycles synthesis and investigation of properties (2013-2016).
- L. Ignatovich (WP 2 leader). Strengthening the research and innovation capacities of the
Latvian Institute of Organic Synthesis, the leading Baltic regional centre for drug
discovery. InnovaBalt. Project Coordinator LIOS director, Professor
Ivars Kalvinsh. Project Manager LIOS, Head of the Laboratory of Pharmaceutical
Pharmacology Dr. Maija Dambrova
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Last update 09.02.2016