Lubov IGNATOVICH

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Dr.habil.chem.
Lubov IGNATOVICH

Principal scientist
Head of the Laboratory of Organometallic Chemistry
Latvian Institute of Organic Synthesis

21, Aizkraukles str.,
Riga, LV-1006, Latvia

Phone: +371 7553355; +371 29590575
e-mail: ign@osi.lv; luba@ignatovica.lv

 

Born: 1953 July 8,   Rezekne, Latvia

Interests:

Languages: Russian, Latvian, English

Education:

Experience:    Latvian Institute of Organic Synthesis –

  Visiting researcher:

Awards:

Plenary and invited Lectures:

Representative Publications:

  1. Lukevics E., Gar T.K., Ignatovich L.M., Mironov V.F. Biological activity of germanium compounds.- Riga: Zinatne,1990.-191p. (in Russian).
  2. Lukevics E., Ignatovich L. Uracil derivatives of Group 14 elements // Frontiers of organogermanium, -tin and -lead chemistry / Ed. By E. Lukevics, L.Ignatovich. – Riga: IOS,1993, 331-341.
  3. Lukevics E., Ignatovich L. Toxicity of organogermanium compounds. The chemistry of organic germanium, tin and lead compounds / ed. By S. Patai. – Chichester: John Wiley & Sons, 1995, 857-863.
  4. Belyakov S., Ignatovich L., Lukevics E. Concerning the transannular bond in silatranes and germatranes: a quantum chemical study // J. Organomet. Chem. , 1999, 577, 205-210.
  5. Lukevics E., Ignatovich L., Belyakov S. Synthesis and molecular structure of phenyl and tolylgermatranes // J. Organomet. Chem., 1999, 588, 222-230.
  6. Kira M., Ishida S., Ichinohe M., Kabuto C., Ignatovich L., Sakurai H. Synthesis and structure of a stable cyclic dialkylgermylene // Chem. Letters ,1999, 263-264.
  7. Hashimoto H., Yagihashi Y., Ignatovich L., Kira M. Characterization and properties of 1,2-Disiladigerma-cyclobutane // Heteroatom Chem., 2001, 12,.398-405.
  8. Ignatovich L., Zarina Dz., Shestakova I., Germane S., Lukevics E. Synthesis and biological activity of silyl- and germylsubstituted trifluoroacetylfurans // Metal-Based Drugs, 2002, 8, 211-214.
  9. Lukevics E., Ignatovich L. Biological activity of organogermanium compounds. The Chemistry of Organic Germanium, Tin and Lead Compounds. Ed. Z.Rappoport, Chichester: John Wiley & Sons Ltd. 2002, 1651-1683.
  10. Lukevics E., Ignatovich L, Shul’ga T., Belyakov S. Synthesis, molecular structure and biological activity of bromobenzylgermatranes // J. Organomet. Chem., 2002, 659, 165-171.
  11. Lukevics E., Ignatovich L., Shestakova I.Synthesis, psychotropic and anticancer activity of 2,2-dimethyl-5-[5’-trialkylgermyl-(silyl)-2’-hetarylidene]-1,3-dioxane-4,6-diones and their analogues //Appl. Organomet. Chem., 2003, 17, 898-905.
  12. Lukevics E., Ignatovich L. Biological Activity of Organosilicon Compounds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine. Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(5), 83-107.
  13. Lukevics E., Ignatovich L. Biological Activity of Organogermanium Compounds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine. Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(15), 279-295.
  14. Ignatovich L., Zarina D., Shestakova I., Germane S., Lukevics E. Synthesis and biological activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes. Organosilicon Chemistry VI: Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA. 2005, From Molecules to Materials. Vol.1, Chapter 1, 563-568.
  15. Lukevics E., Ignatovich L., Sleiksha I., Shestakova I., Domrachova I., Popelis J. Synthesis and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes and their thiosemicarbazones. //Appl. Organomet. Chem., 2005, 19, 1109-1113.
  16. Ignatovich L., Popelis J., Lukevics E. Synthesis and NMR spectra of dyaryl- and dihetarylsilacycloalkanes. Organosilicon Chemistry VI: [Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA]. 2005, From Molecules to Materials. Vol.1, Chapter 1, 559-562.
  17. Lukevics E., Ignatovich L., Sleiksha I., Muravenko V., Shestakova I., Belyakov S., Popelis J. Synthesis, structure and cytotoxic activity of 2-acetyl-5-trimethylsilylthiophene(furan) and their oximes. //Appl. Organomet. Chem., 2006, 20, 454-458.
  18. Ignatovich L., Muravenko V., Grinberga S., Lukevics E. Novel reactions to form an Si-O-Ge group. // Chem. Heterocycl. Comp. , (Engl. Ed.). 2006, 42, 268-271.
  19. Lukevics E., Ignatovich L., Sleiksha I., Romanov V., Grinberga S., Popelis J., Shestakova I. New synthetic way to silicon and germanium containing 2-acetylfurans and –thiophenes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2007, 43, 145-150.
  20. Lukevics E., Ignatovich L., Belyakov S. Disordering in crystal structures of thienylgermatranes.// Chem. Heterocycl. Comp. (Engl. Ed.). 2007, 43, 243-249.
  21. Soualami S., Ignatovich L., Lukevics E., Ourari A., Jouikov V. Electrochemical oxidation of benzylgermatranes.// J. Organomet. Chem., 2008, 693, 1346-1352.
  22. Lukevics E., Ignatovich L., Shul'ga T., Belyakov S. Synthesis and crystal structure of 1-(4-fluorophenyl)-  and 1-(4-dimethylamino)phenylgermatranes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2008, 44, 615-620.
  23. Ignatovich L., Muravenko V., Shestakova I.,Domracheva I., Popelis J., Lukevics E.  Synthesis and cytotoxic activity of new 2-[(3-aminopropyl)dimethylsilyl]-5-triethylsilylfurans. //Appl. Organomet. Chem., 2010, 24(3), 158 - 161.
  24. Ignatovich L., Romanovs V.,  Shestakova I.,Domracheva I., Popelis J., Lukevics E.  Synthesis and biological activity of new 2-[(3-aminopropyl)dimethylsilyl]-5-trialkylgermylfurans. //Khim. Geterocikl. Soed., 2009, 12, 1792-1799.
  25. Lukevics E., Abele E., Ignatovich L.  Biologically Active Silacyclanes. // In:  Advances in Heterocyclic Chemistry, 2010, Vol. 99, 107-141.
  26. Soualmi S., Ignatovich L., Jouikov V. Cation radicals of organogermatranes.// Appl. Organomet. Chem. 2010, 24(12), 865-87.
  27. Ignatovich L., Romanovs V., Spura J., Popelis J., Domracheva I., Shestakova I. Synthesis and antitumor activity of 3-[(Methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines. //Chem.Heterocycl.Comp. (Engl. Ed.), 2011, 47(12), 1502-1508.
  28. Ignatovich L., Muravenko V., Spura J., Popelis J., Domrachova I., Shestakova I. Synthesis, Structure and Cytotoxicity of New 2-[(3-Aminopropyl)dimethylsilyl]-5-furfural Diethylacetals and 2-[(3-Aminopropyl)-dimethylsilyl]-5-phenylfurans. //Appl. Organomet.Chem., 2013, 27(7), 406-411.
  29. Ignatovich L., Starkova O., Romanovs V., Sleiksha I., Shestakova I., Popelis J., Lukevics E. Novel Trialkylsilyl(germyl)-substituted Thienyl- and Furylbenzimidazoles and their N-Substituted Derivatives – Synthesis, Structure and Cytotoxic activity. //Comptes Rendus Chimie, 2013, 16(6), 521-627.
  30. Ignatovich L., Jouikov V. Organogermatranes and their cation radicals by EPR-spectroelectrochemistry and ab initio calculations. //J. Organomet. Chem. 2014, 751, 546-554. http://dx.doi.org/10.1016/j.jorganchem.2013.08.007
  31. Ignatovich L., Romanovs V., Muravenko V., Sleiksha I., Popelis J., Shestakova I. Synthesis and Cytotoxic Activity of 1-{3-[1-(5-Organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and Some Trimethylgermyl Analogues. //Chem.-Eur. J. 2014, 20(40), 12786-12788.
  32. Ryabova V., Ignatovich L. Thiophene Substitution Chemistry. /DOI 10.1007/7081_2014_134/. Topics in Heterocyclic Chemistry 2015, Ed. John A Joule, Springer, Switzerland, Vol.39, 43-108.
  33. Ignatovich L., Spura J., Muravenko V., Beďakovs S., Popelis J., Shestakova I., Domrachova I, Gulbe A., Rudevica Z., Leonchik A. Synthesis, structure and biological activity of new 6,6-dimethyl-2-oxo-4-{2-[5-organylsilyl(germyl)]furan(thiophen)-2-yl}vinyl-5,6-dihydro-2H-pyran-3-carbonitriles. //Appl. Organomet. Chem. 2015, 29(11), 756-763.

Research Projects:



Last update 09.02.2016