Edgars ABELE
|
Dr.habil.chem.
Edgars Abele Latvian Institute of Organic Synthesis
Aizkraukles 21, Riga, LV-1006, Latvia
Phone: (371) 7551822
Fax: (371) 7550338
E-mail: abele@osi.lv |
Born: January 22, 1962, Riga, Latvia
Interests:
- Phase Transfer Catalytic Synthesis (experimental an theoretical investigation of
reactions of oximes, perhalogenalkanes and silanes etc.)
- Transition Metal Complex Catalysis
- Elaboration of Novel Bicatalytic Systems (transition metal complex and phase transfer
catalysis)
- Medicinal Chemistry (cholesterol level lowering and cytotoxic activities of synthesized
silicon and sulphur containing aromatic and heteroaromatic compounds)
Scientific publications: ~ 160
Education:
Riga Technical University, Faculty of Chemistry (1980-1985)
Candidate of Science in former USSR (1991)
Dr.chem. thesis Phase transfer catalytic reactions of N-, O- and
S-heterocyclic compounds (1992)
Dr.habil.chem. thesis Nucleophilic substitution, halogenation, and
cycloadition reactions of acyl-, alkenyl- and alkynyl derivatives of arenes and hetarenes
under phase transfer catalysis conditions (1999)
Experience:
Junior Researcher, Latvian Institute of Organic Synthesis
Researcher (1993)
Leading Researcher (2003)
Head of Modern Catalysis Methods Group (2003)
Recent representative publications (2000-2007):
- E. Abele, K. Rubina, O. Arsenyan, S. Grinberga, J. Popelis, E.
Lukevics. Fluoride ion-mediated reactions of disubstituted acetylenes Me3SiC
CMMe3 (M = C, Si, Ge, Sn) with aldehydes and ketones. - Main
Group Metal Chem., 2000, vol. 23, N 4, pp. 243-252.
- E. Abele, R. Abele, J. Popelis, E. Lukevics. Novel
stereoselective synthesis of E-aryl aldoxime and ketoxime O-ethers. - Org. Prep.
Proced. Int., 2000, vol. 32, N 2, pp. 153-159.
- K. Rubina, E. Abele, P. Arsenyan, R. Abele, M.
Veveris, E. Lukevics. Synthesis of silicon and germanium containing heteroaromatic
sulfides as cholesterol level lowering and vasodilating agents. - Metal-Based Drugs,
2001, vol. 8, N 2, pp. 85-93.
- E. Abele, M. Fleisher, K. Rubina, R. Abele, E. Lukevics.
Halogenation of terminal acetylenes by perhalogenalkanes under phase transfer catalysis
conditions. - J. Molecular Catalysis A: Chemical., 2001, vol. 165, N 1-2, pp. 121
126.
- E. Lukevics, K. Rubina, E. Abele, M. Fleisher, P.
Arsenyan, S. Grinberga, J. Popelis. Fluoride ion mediated reactions of
disubstituted acetylenes Me3SiCCMMe3 (M = C, Si, Ge, Sn) with
terminal acetylenes. - J. Organomet. Chem., 2001, vol.
634, N 1, pp. 69-73.
- E. Abele, O.Dzenitis, K. Rubina, E. Lukevics. Synthesis of N-
and S-vinyl derivatives of heteroaromatic compounds using phase transfer catalysis. -
Chem. Heterocycl. Comp., 2002, vol. 38, N 6, pp. 682-685.
- E. Abele, K. Rubina, R. Abele, O. Dzenitis, P. Arsenyan, J. Popelis,
M. Veveris, D. Meirena, E. Lukevics. Silacyclic derivatives of heteroaromatic sulfides as
selective cholesterol level lowering and vasodilating agents. - Metal-Based Drugs,
2002, vol. 8, N 6, pp. 307-313.
- E. Abele, K. Rubina, M. Fleisher, J. Popelis, P. Arsenyan, E.
Lukevics. Synthesis of unsymmetric diynes by palladium catalyzed coupling of terminal
bromoalkynes with alkynylstannanes.- Appl. Organomet. Chem., 2002, vol 16,
N 3, pp. 141-147.
- R. Abele, E. Abele, K. Rubina, O. Dzenitis, P. Arsenyan, I.
Shestakova, A. Nesterova, I. Domracheva, J. Popelis, S. Grinberga, E. Lukevics. Synthesis
and cytotoxicity of 3-(hetarylthio)-1-propynyl(trimethyl)silanes. - Chem.
Heterocycl. Comp., 2002, vol. 38, N 7, pp. 867-872.
- E. Abele, O. Dzenitis, J. Popelis, E. Lukevics. Novel fluoride ion
mediated method for rapid silylation of carboxylic acids with azidotrimethylsilane under
phase transfer catalysis conditions. - Main Group Metal Chemistry, 2002, vol. 25,
pp. 585-587.
- E. Lukevics, E. Abele, P. Arsenyan, R. Abele, K. Rubina, I.
Shestakova, I. Domracheva, V. Vologdina. Synthesis and cytotoxicity of silicon containing
pyridine and quinoline sulfides. - Metal-Based Drugs, 2002, vol. 9, N 1-2,
pp. 45-51.
- R. Abele, E. Abele, M. Fleisher, S. Grinberga, E. Lukevics. Novel
fluoride ion mediated synthesis of unsymmetric siloxanes under phase transfer catalysis
conditions. - J. Organomet. Chem., 2003, vol 686, pp. 52-57.
- P. Arsenyan, K. Rubina, I. Shestakova, E. Abele, R. Abele, I.
Domracheva, A. Nesterova, J. Popelis, E. Lukevics, Synthesis and cytotoxicity of
silylalkylthio-substituted N-heterocycles and their hydroselenites . - Appl.
Organomet. Chem., 2003, vol. 17, pp.825-830.
- K. Rubina, M. Fleisher, E. Abele, J. Popelis, E. Lukevics,
Prototropic rearrangement of N-, O- and S-propargyl derivatives under phase transfer
catalysis conditions: mechanisms and limitations . - Zh. Org. Khim., 2003,
vol. 39, N 7, pp.1024-1028 (in Russian).
- K. Rubina, E. Abele, J. Popelis, S. Grinberga, P. Arsenyan, E.
Lukevics. Novel stereoselective phase transfer catalytic synthesis and some applications
of (E)-2-chlorovinylthioarenes and hetarenes. - Phosphorus, Sulfur, and Silicon
and the Related elements, 2003, vol. 178, N 3, pp. 531-529.
- K. Rubina, E. Abele, P. Arsenyan, M. Fleisher, J. Popelis, A.
Gaukhman, E. Lukevics, The role of palladium catalyst and base in stereoselective
transformations of (E)-2-chlorovinylsulfides. - Tetrahedron, 2003, vol. 59, pp.
7603-7607.
- E. Abele, R. Abele, P. Arsenyan, I. Shestakova, I. Kanepe, I.
Antonenko, J. Popelis, E. Lukevics. Synthesis and cytotoxicity of silicon and germanium
containing pyridine oxime O-ethers . - Bioinorg. Chem. Appl., 2003, vol. 1, N
3-4, pp. 299-308.
- E. Abele, R. Abele, P. Arsenyan, E. Lukevics. A new pathway for the
preparation of diaryl acetylenes. - Tetrahedron Letters, 2003, vol. 44, N 20, pp.
3911-3913.
- R. Abele, L. Zvejniece, E. Abele, K. Rubina, P. Arsenyan, M. Vandish,
O. Pudova, M. Dambrova, I. Domracheva, I. Shestakova, J. Popelis, E. Lukevics. Synthesis
and neurotropic activity of silyl propargyl alcohols and sulfides. - Appl. Organomet.
Chem. , 2004, vol. 18, N 4, pp. 181-186.
- E. Abele, J. Popelis, I. Shestakova, I. Domracheva, P. Arsenyan, E.
Lukevics. Synthesis and cytotoxicity of derivatives of di(3-indolyl)selenides - Chem.Heterocycl.
Comp. (Engl. Ed.), 2004, vol. 40, N6, 742-746.
- P.Arsenyan , R.Abele, S. Belyakov, E.Abele, E.Lukevics. The
crystal structure of
bis-(3,3dimethyl-3,4-dihydro-2H-1-thia-4a,9-diaza-3-sila-fluorene) silver nitrate.
- Appl. Organomet. Chem., 2005, vol. 19, N 7, pp.875-876.
- E.Abele, K.Rubina, S.Belyakov, M.Fleisher, J.Popelis. Unusual
protonation of oxime nitrogen in acetophenone O-[3-(5-tetrazolyl)propyl]oxime in solid
state. - Heterocycl. Commun., 2006, 12(3-4), 259-264.
- E.Abele, M.Veveris, R.Abele, K.Rubina, P.Arsenyan, D.Meirena.
3-(Hetarylthio)-1-propynyl(dimethylalkyl) silanes as selective cholesterol level lowering
agents. - Main Group Met.Chem., 2006, vol. 29, N 4, pp.
215-219.
Reviews
- E. Abele, E. Lukevics. Reactions of carbon
tetrachloride and carbon tetrabromide with anions and carbanions. - Org.
Prep. Proced. Int. 1999. Vol. 31, N 4. P. 359-377.
- E. Abele
, E. Lukevics, Recent advances in the chemistry
of oximes. - Org. Prep.Proced. Int. 2000. Vol.
32, N 3. P. 235-264.
- E. Abele
, E. Lukevics. Recent advances in the synthesis
of heterocycles from oximes. - Heterocycles, - 2000. Vol. 53, N 10
P. 2285-2336.
E. Abele, E. Lukevics. Recent advances in
asymmetric phase transfer catalysis. - Latv.J.Chem., - 2001. - Nr. 1.
- pp. 3.-14.
- E. Abele,
E. Lukevics. Recent advances in transition
metal-catalyzed coupling reactions of silanes under fluoride ion activation. - Latv.J.Chem.,
2001, N 4, pp. 327-328.
- E. Abele
, E. Lukevics. Recent advances in fluoride ion
activation of silicon bonds in organic synthesis. - Main Group Met. Chem. - 2001.
- Vol. 24, Nr. 6. - P. 315- 350.
- E. Abele
, E. Lukevics. Recent advances in the synthesis
and transformations of heterocycles mediated by fluoride ion activated organosilicon
compounds. - Heterocycles, 2002, vol 57, N 2, pp. 361-404.
- E.Abele, R.Abele, K.Rubina, E.Lukevics. Quinoline oximes:
synthesis, reactions, and biological activity: [review]. - Chem.Heterocycl.
Comp. (Engl. Ed.)., 2005, vol. 41, N 2, pp.137-162.
- E. Abele. Activation of silicon bonds by fluoride ion in the organic
synthesis in the new Millenium: [a review]. - - Main Group Met.Chem., 2005,
28(2), pp. 45-69.
E. Abele,
R.Abele, E. Lukevics. Oximes of five-membered
heterocyclic compounds with two heteroatoms. 1. Synthesis and structure [Review] . -
Chem.Heterocycl. Comp. (Engl. Ed.)., 2007, vol. 43, N 4, pp.
387-407.
Research Projects:
- E. Abele (Head of Project ). Silicon and Germanium
Containing N- and S-heteroaromatic Sulfides as Cholesterol Level Lowering Agents Acting on
Blood Circulatory System. Latvian Council of Science (2001-2004)
Last update 29.10.2007