Regina ZHUK

ZHUK.JPG (6459 bytes) Professor Regina ZHUK
Department Director,
Rimonyx Pharmaceuticals, Ltd.
Kiryat Weizmann Science Park

Ness-Ziona 70400
P.O.Box 4056
Israel

Home:
Hatayasim 14/11
Nes Ziona 74062
Israel

Phone: +972-89389505
E-mail: reginazhuka@gmail.com

 
          

 

Born: December 6, 1936, Moscow, Russia

Interests:

Brief Description of Main Research:

Two original drugs designed - anticancer Ftorafur ( Tegafur ) and antiviral Furavir. Technologies for Ftorafur, Acyclovir and Furavir large scale production elaborated.  A series of 7(9)-substituted guanines is synthesized and evaluated as immunomodulating agents. A new trend of   research is connected with the investigation of  butyric acid derivatives as anti-cancer drugs and thieno[2,3-c]pyridines as anti-inflammatory agents.

    - 125 scientific papers and abstracts published;
    - 45 author's certificates and patents granted
    -  6 PhD students and 20 Master's degree students supervised

Languages: Russian, Latvian, English

Education:

Experience:

Latvian Institute of Organic Synthesis:

Bar Ilan University (Israel):

Honours and Awards:

Professional Activities and Memberships:

Lectures:

International Collaboration:

 

Recent/Representative Publications:

  1. S.A.Hiller, R.A.Zhuk, M.Yu.Lidak. Pyrimidine nucleoside analogues. I. N1-(a-furanidyl)derivatives of natural pyrimidine bases and their antimetabolites. - Dokl. Akad. Nauk SSSR, 1976, N 2, pp.332-335 (1967) (in Russian).
  2. S.A.Hiller, R.A.Zhuk, L.A.Sherinya, D.E.Zarin. 1-(a,w-Dihydroxyalkyl)uracils and their phosphates. - Nucleic Acids Res., Spec., 1975,. Publ. N 1, pp.169-171.
  3. S.A.Hiller, D.E.Zarin, R.A.Zhuk, Pyrimidine nucleoside analogues X. 5-Substituted 1-(1,3-Dihydroxypropyl-2)uracils. - Nucleic Acids Res., 1976,. 3(3), pp. 721-727.
  4. R.A.Zhuk, A.E.Berzin, V.N.Silin, E.E.Liepinsh, 2-(5-Substituted uracil-1-yl) tetrahydrofuran-5-carboxylic acids as pyrimidine ucleotide analogues. - Nucleic Acids Res., Spec., 1978, Publ. N 3, pp. 19-22.
  5. Ftorafur. An Antitumor Drug.(Ed. by R.A.Zhuk), 1979, Riga: Zinatne.
  6. R.A.Zhuk, L.T.Kaulinya, A.S.Ludzisha, E.E.Liepinsh, M.Yu.Lidak. Tetrahydrofuryl- and alkopxyalkyl analogues of pyrimidine nucleosides. - Nucleic Acids Res., Symp. Ser., 1981, N 9, pp.123-125.
  7. A.S.Ludzisha, Je.G.Shpaer, R.A.Zhuk, M.P.Eninsh, N.J.Ghuyeva, Ja.A.Eiduss. Nucleic Acids Res., Symp. Ser., 1984, N 14, pp. 227-229.
  8. R.Zhuk, M.Y.Lidak, A.A.Zidermane, A.Gilev. Correlation between structure and activity in substituted 5-fluorouracils, in Ftorafur, Proceedings of the International Symposium, Ed. by R.A.Zhuk, 1985, Riga: Zinatne, pp. 16-26.
  9. M.A.Madre, R.A.Zhuk, M.Y.Lidak. Purine nucleoside analogues. 4. 7-Alkylated 9-(2-hydroxymethyl)guanine. - Chem. Heterocycl. Comp., 1989, vol. 25, N 5, pp. 535-540.
  10. A.A.Golbraikh, J.Betins, J.Balodis, R.A.Zhuk, G.V.Nikiforovich. Conformational aspects of antiviral activity of deoxyguanosine acyclic analogues. - Nucleic Acids Res., 1989, vol. 17, pp. 7965-7977.
  11. M.Madre, R.Zhuk, M.Lidak. New Prodrugs of Acyclovir with antiviral activity. -Nucleosides & Nucleotides, 1991, vol.10, pp. 279-282.
  12. M.A.Madre, R.A.Zhuk, M.Y.Lidak. Purine nucleoside analogues. 5. Acycloguanosine derivatives, containing O-alkoxyalkyl substituent in the acyclic moiety.- Bioorg. Khim., 1991, vol. 17, N 11, pp. 1516-1520 (in Russian).
  13. R.A.Zhuk, M.A.Madre, A.V.Ananiev, L.G.Pogosyan, Zh.J.Akopyan. Antiviral and immunomodulating activity of acyclic guanosine analogues. - Abstr. of Papers XIIth Intern. Symp. of Medicinal Chemistry, Basel, Switzerland, Sept. l3-17, 1992, p.333.
  14. M.A.Madre, R.A.Zhuk, M.Y.Lidak. Purine nucleoside analogues. 6. Chlorination of acycloguanosine and its derivatives with thionyl chloride. - Chem. Heterocycl. Comp. 1992, vol. 28, N 5, pp. 567-569.
  15. R.A.Zhuk, M.A.Madre. Synthesis of 7,8-disubstituted guanines as potential PNP inhibitors. - Abstr. of Papers 4th Intern. Symp. on Molecular Aspects of Chemotherapy , 23-25 June 1993, Gdansk-Poland, p.56 (1993).
  16. R.A.Zhuk, M.A.Madre. Synthesis of 7-(2-hydroxymethyl)guanine and related compounds as immunomodulators. - Nucleic Acids, Symp. Ser.., 1994, N 31, pp. 5-6.
  17. M.A.Madre, L.Geita, R.A.Zhuk, G.-J.Koomen. Purine Nucleoside Analogues. 7*. 9-[2-(Alkylthio)ethoxymethyl]Derivatives of Adenine, Hypoxanthine and Guanine. - The Chinese Pharmaceutical Journal, 1995, vol. 47, pp. 469-481.
  18. M.A.Madre, R.A.Zhuk, N.Panchenko, J.A.J.Geenevasen, A.M. van den Burg, G.-J.Koomen. Some peculiarities of N2-acetyl-8-bromoguanine alkylation. - Coll. Czech. Chem. Commun., 1996, vol. 61, sp. issue, pp. 20-22.
  19. M.A.Madre, R.A.Zhuk, G.-J.Koomen. Addition of 2,3-dihydrofuran to N2-acetyl-8-bromoguanine. – Nucleosides&Nucleotides., 1997, vol. 6, N 7-9, pp.1107-1110.
  20. R.A.Zhuk, M.A.Madre, M.Khan, L.Poluektova. Immunosuppressive effects of 8-bromoguanine derivatives. - 6th Intern. Symp. on Molecular Aspects of Chemotherapy, Gdansk, Poland, 9-12 July 1997: Abstr. book, 1997, p. 135.
  21. R.A.Zhuk. Structure-activity relationship in ftorafur (tegafur) and related 5-FU prodrugs, Adv. in experimental medicine and biology. - 1998 - Vol. 431: Purine and pyrimidine metabolism in man IX, (Ed. A. Griesmacher, P. Chiba, M.M. Muller). - New York: Plenum Press, 1998, pp. 677-680.
  22. M.A.Madre, R.A.Zhuk, B.Golankiewicz. Purine nucleoside analogues. 8. N2-Acety-lation of guanine derivatives. - Polish J. Chem., 1998, vol. 72, N 10, pp. 2242-2246.
  23. M.A. Madre, R.A. Zhuk, N. Panchenko, J. Geenevasen, A.M. van den Burg, G.-J. Koomen. Purine nucleoside analogues. 10. A new synthetic route to 8-substituted-7(9)-alkoxyalkylguanines. - Heterocyclic Communications, 1998, vol. 4, N 6, pp.581-588.
  24. A.Rephaeli, R.Zhuk, A.Nudelman. Prodrugs of butyric acid from bench to bedside: synthetic design, mechanisms of action, and clinical applications. - Drug Dev. Res., 2000, vol. 50, pp. 379-391.
  25. Y.Zimra, A.Nudelman, R.Zhuk, E.Rabizadeh, M.Shaklai, A.Aviram, A.Rephaeli. - J.Cancer Res. Clin. Oncol., 2000, vol. 126, pp. 693-698.
  26. A.Nudelman, E.Gnizi, Y.Katz, R.Azulai, M.Cohen-Ohana, R.Zhuk, S.R.Sampson, L.Langzam, E.Fibach, E.Prus, V.Pugach, A.Rephaeli. Prodrugs of butyric acid. Novel derivatives possesssing increased aqueous solubility and potential for treating cancer and blood diseases. - Eur. J. Med., 2001, vol. 36, pp. 63-74.

Patents granted:

  1. Brit. Pat. 1,168,391 (1969).
  2. US Pat. 3,635,946 (1972).
  3. US Pat. 3,912,734 (1975).
  4. US Pat. 3,947,444 (1976).
  5. US Pat. 3,954,760 (1976).
  6. US Pat. 4,916,225 (1990).

 

Research Projects:



Last update 05.02 .2008