Edmunds LUKEVICS
(14.12.1936 - 21.11.2009)
Born: December 14, 1936, Liepaja, Latvia
Departed: November 21, 2009, Riga, Latvia
Interests:
- Organometallic Compounds
- Heterocyclic Compounds
- Biological Activity of Organic Compounds
Main Research:
Development of methods for the synthesis of organosilicon and -germanium derivatives of
furan, thiophene and nitrogen-containing heterocycles ; study of the influence of
organosilicon ,-germanium and -tin substituents on the direction of substitution and
addition reactions of furan and thiophene derivatives ; study of hydrosilylation and
hydrogermylation reactions, synthesis and investigation of properties of penta- and
hexacoordinated organosilicon and -germanium derivatives; application of alkenyl silanes
and germanes in the synthesis of nitrogen-containing heterocycles; application of
phase-transfer catalysis and ultrasonic irradiation in organometallic synthesis; synthesis
of biologically active organosilicon and organogermanium compounds and studies of their
properties.
Education:
- University of Latvia (Faculty of Chemistry), 1958
- Dr.chem. (Candidate of Science in former USSR, Ph.D. in Western countries), Latvian
Academy of Sciences, Riga, 1966
- Dr.habil.chem. (Doctor of Science in former USSR), Latvian Academy of Sciences,
Riga, 1973
Experience:
Latvian Institute of Organic Synthesis -
- Junior Researcher, 1958-1967
- Senior Researcher, 1968-1970
- Head, Laboratory of Organometallic Chemistry, 1970 - 2009
- Vice-director, 1980-1982
- Director, 1982 - 2003
Honours and Awards:
- Corresponding Member, Latvian Academy of Sciences , 1982
- Full Member, Latvian Academy of Sciences , 1987
- Member, New York Academy of Sciences, 1993
- The Latvian Academy of Sciences Gustavs Vanags Prize (in Chemistry), 1986
- Latvian SSR State Prize, 1974, 1989
- S.Hiller Medal (Latvian Institute of Organic Synthesis), 1990
- G.Vanags Medal (Riga Technical University), 1991
- D.H.Grindel Medal (company Grindex, Latvia), 1995
- L.Liepina Medal (Institute of Inorganic Chemistry, Riga), 1996
- The Latvian Academy of Sciences Grand Medal, 1996
- Silver Medal of Milan University, 1996
- Schmiedebergs Medal (Latvian Pharmacological Society), 1998
- The Latvian Academy of Sciences and Company "GRINDEX" Prize, 1999
- Paul Walden's Medal (Riga Technical University), 2000
- Latvian Academy of Sciences Presidium Award, 1971, 1973, 1977, 1981, 1982,
1985,1987, 1989, 1992
- International Man of the Year (The International Biographic Centre of Cambridge,
England), 1992-1993, 1994-1995
- Man of the Year (The American Biographical Institute), 1994, 2005
- The first-level Badge of Honour of the Order of Three Stars, 1997
- Company Grindex gold badge of honour, 2001
- The Cabinet of Ministers of the Republic of Latvia Prize , 2004
- American Medal of Honor (ABI), 2005
- Gold Medal for Latvia (ABI), 2006
- The Plato Award (IBC), 2006
- Man of Achievement (ABI), 2007
Professional Activities:
- Member of Presidium and Senate, Latvian Academy of
Sciences, 1987-1991
- Member of Board, Division of Chemical and Biological Sciences, Latvian Academy of
Sciences, 1983-1993
- Member, Latvian Academy of Sciences Commission on Terminology, 1987- 1999
- Chairman, Habilitation and Promotion Council (Chemistry and Pharmacy), Latvian Institute
of Organic Synthesis, 1994 -1999
- Member (Chairman,1991-1993, 1997-2002), Latvian Council of Science Expert Committee for
Chemistry, 1991 - 2006
Vice-chairman, Habilitation and Promotion Council (Chemistry),
University of Latvia, 1998- 2009
Member of Editorial Board for:
Khimiya Geterotsikicheskikh. Soedinenii (Chemistry of Heterocyclic Compounds,
Springer), 1980-1985; Editor-in-chief, 1985 - 2009
Proceedings of Latvian Academy of Sciences, 1982-1990
Latvian Journal of Chemistry, 1991 - 2009
Bioorganicheskaya Khimiya, 1989 - 1993
Applied Organometallic Chemistry, 1990 - 2009
Main Group Metal Chemistry, 1992 - 2009
Metal-Based Drugs, 1993 - 2003
Mendeleev Communications, 1994 - 2009
Advances in Heterocyclic Chemistry, 1994 - 2009
Silicon Chemistry, 2001-2007
Arkivoc, 2001 - 2009
Bioinorganic Chemistry and Applications, 2003 - 2006
Heterocyclic Communications, 2005 - 2009
Molecules, 2008 - 2009
Journal of Organic and Pharmaceutical Chemistry (Ukraine), 2009 - 2009
- Chairman, Scientific Council Chemistry and Technology of Sulfur Organic
Compounds, USSR State Committee of Science and Technics, 1982-1987
- Chairman, Council Application of Organometallic Compounds in National
Economy, USSR (Russian) Academy of Sciences, 1984-1992
- Member, United Libraries Informative Council, USSR Academy of Sciences, 1985-1990
- Member, Scientific Council Physiologically Active Compounds, USSR Academy of
Sciences, 1986-1992
- Member, Scientific and Technical Council, USSR Ministry of Medical and Microbiological
Industry, 1987-1990
- Member, Soviet National Committee on collecting and estimating information in science
and technics CODATA, 1987-1990
- Member of Council for Coordination of scientific work, Department of Biochemistry,
Biophysics and Physiologically Active Compounds, USSR Academy of Sciences, 1988-1991
- Member of International Organizing Committees
- International Conference on the Coordination and Organometallic
Chemistry of Germanium, Tin and Lead, 1992, 1995, 1998, 2001
- International Symposium on Organosilicon Chemistry, 1993, 1996,
1999, 2002, 2005, 2008.
Memberships:
- Member of Organometallic Chemistry Division, Federation of European Chemical Societies,
1995-2005
- Member of Organometallic Chemistry Division, European Association for Chemical &
Molecular Sciences, 2006
- Member, Latvian Chemical Society, 1995
- Member, American Chemical Society, 1997
- Member, National Geographic Society, 1997
- Honorary Member, Pharmacological Society of Latvia, 1998
Lectures
Invited Lectures at Universities
- Indian Institute of Science, Bangalore (India), 1989
- Indian Institute of Technology, Bombay (India), 1989
- University of Dresden (Germany), 1989
- Universities of Bordeaux, Tolouse, Montpellier, Marseilles (France), 1990, 1994
- University of Lund (Sweden), 1992
- University of Alcala de Henares ( Spain), 1993
- Tohoku University (Sendai, Japan), 1991, 1992
- Tokyo University of Science (Japan), 1997
- Kyoto University (Japan), 1997
- Universities of Kyoto and Kanagawa, Japan, 2002.
Invited Lectures and Symposiums Plenary Lectures:
- 40th Nobel Symposium (Lidingö, Sweden), 1977
- VI Symposium on Chemistry of Heterocyclic Compounds (Brno, Czechoslovakia), 1978
- 7th International Symposium on Organosilicon Chemistry (Kyoto, Japan), 1984
- VI FECHEM Conference on Organometallic Chemistry (riga, Latvia), 1985
- II Soviet-Indian Symposium on Organometallic Chemistry( Irkutsk, Russia), 1989
- 17th DDR-Poland Colloquy on Organometallic Chemistry (Holzhau, Germany), 1989
- 6th International Conference on Organometallic and Coordination Chemistry of Germanium,
Tin and Lead (Brussels, Belgium), 1989
- Huang Minlon Symposium on Organic Chemistry (Shanghai, China), 1989
- International Chemical Conference on Silicon and Tin ( Kuala Lumpur, Malaisia), 1989
- 9th International Symposium on Organosilicon Chemistry (Edinburgh, UK), 1990
- 1st Meeting of the European Society of Sonochemistry, Autrans (Grenoble, France), 1990
- 11th International Symposium on Medicinal Chemistry (Jerusalem, Israel), 1990
- S.Hiller Memorial Lectures (Riga, Latvia), 1990
- 1st Meeting of Japanese Germanium Discussion Group (Tokyo, Japan), 1991
- International Conference on Environmental and Biological Aspects of Maingroups
Organometals (Padua, Italy), 1991
- 3rd Swedish-German workshop: Nucleic Acid Synthesis, Structure and Function (Uppsala,
Sweden), 1992
- 2nd ANAIC Conference on Materials Science and Environmental Chemistry of Main Group
Elements (Kual Lumpur, Malaysia), 1993
- Todai Symposium Ge-Sn-Pb Tokyo93: International Symposium on Organic,
Bioorganic and Bioinorganic Chemistry of Compounds of higher row Group 14-elements (Tokyo,
Japan), 1993
- 10th International Symposium on Organosilicon Chemistry (Poznan, Poland), 1993
- 3rd Meeting of the European Society of Sonochemistry (Figueira da Foz, Portugal), 1993
- 14th Nordic Meeting of Structural Chemists (Helsinki, Finland), 1993
- 8th International Conference on the Organometallic Chemistry of Germanium, Tin and Lead
(Sendai, Japan), 1995
- 8th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
(Santa Barbara, USA), 1995
- 8th Symposium Heterocycles in Bioorganic Chemistry (Como, Italy), 1996
- 9th International Conference on the Coordination and Organometallic Chemistry of
Germanium, Tin, and Lead (Melbourne, Australia), 1998
- 12th International Conference on Organosilicon Chemistry (Sendai, Japan), 1999
- International Conference on Organic Synthesis "Balticum Organicum
Sinteticum-2000"(Vilnius, Lithuania), 2000
- X International Symposium "Jubilee Krka Prizes" (Novo Mesto, Slovenia), 2000
Recent/Representative Publications:
- E.Ya. Lukevits, M.G.Voronkov. Organic Insertion Reactions of Group IV Elements, 1966,
New York: Consultants Bureau, 413 pp.
- S.N.Borisov, M.G.Voronkov, E.Ya.Lukevits. Organosilicon Heteropolymers and
Heterocompounds, 1970, NewYork: Plenum Press, 633 pp.
- S.N.Borisov, M.G.Voronkov, E.Ya.Lukevits. Organosilicon Derivatives of Phosphorus and
Sulfur, 1971, NewYork; London: Plenum Press, 343 pp.
- M.G.Voronkov, G.I..Zelchan, E.Ya.Lukevits. Silizium und Leben, 1975, Berlin:
Akademie-Verlag, 370 pp.
- E.Lukevics, O.Pudova, R.Sturkovich. Molecular Structure of Organosilicon Compounds,
1989, Chichester: Ellis Horwood Ltd., 359 pp.
- E.Lukevics, T.Gar, L.Ignatovich, V.Mironov. Biological Activity of Germanium Compounds,
1990, Riga: Zinatne, 191 pp. (in Russian).
- E.Lukevics, A.Zablocka. Nucleoside Synthesis: Organosilicon Methods, 1991, Chichester:
Ellis Horwood, 496 pp.
- E.Lukevics, L.Ignatovich. Biological activity of organogermanium compounds. - In: The
Chemistry of Organic Germanium, Tin and Lead Compounds/Ed. Z.Rappoport/, Wiley,
Chichester, 2002, vol. 2, pt. 2, pp. 1653-1683.
- E.Lukevics, O.Pudova. Biological activity of organogermanium compounds. - In: The
Chemistry of Organic Germanium, Tin and Lead Compounds/Ed. Z.Rappoport/, Wiley,
Chichester, 2002, vol. 2, pt. 2, pp. 1685-1714.
- E.Lukevics, O.Pudova. Silyl imidic esters. - In: Science of Synthesis, Thieme,
2002, vol. 4, pp. 305-315.
- E. Lukevics, P. Arsenyan, S. Belyakov, O. Pudova. Synthesis, structure and chemical
transformations of ethynylgermatranes Eur. J. Inorg. Chem., 2003, Iss.17,
pp.3139-3143.
- R. Abele, E. Abele, M. Fleisher, S. Grinberga, E. Lukevics. Novel fluoride ion mediated
synthesis of unsymmetrical siloxanes under phase transfer catalysis conditions.
J. Organomet. Chem., 2003, vol.686, N 1/2, pp.52-57.
- E. Lukevics, L. Ignatovich, I.Shestakova. Synthesis, psychotropic and anticancer
activity of
2,2-dimethyl-5-[5-trialkylgermyl(silyl)-2-hetarylidene]-1,3-dioxane-4,6-diones and
their analogues. - Appl. Organomet. Chem., 2003, vol. 17, N 12,
pp.898-905.
- P. Arsenyan, K. Rubina, I. Shestakova, E. Abele, R. Abele, I. Domracheva, A. Nesterova,
J. Popelis, E. Lukevics. Synthesis and cytotoxicity of silylalkylthio-substituted
N-heterocycles and their hydroselenites. Appl. Organomet. Chem., 2003,
vol. 17, N 11, pp.825-830.
- E. Lukevics, L. Ignatovich, T. Shulga, S. Belyakov. The crystal structure of
2-benzo[b]thienylgermatrane. Appl. Organomet. Chem., 2003, vol. 17, N 9,
pp.745-746.
- K. Rubina, E. Abele, P. Arsenyan, M. Fleisher, J. Popelis, A. Gaukhman, E. Lukevics. The
role of palladium catalyst and base in stereoselective tranformations of
(E)-2-chlorovinylsulfides. Tetrahedron, 2003, vol.59, N 38, pp.7603-7607.
- I. Iovel, L. Golomba, J. Popelis, S. Grinberga, E. Lukevics Catalytic hydrosilylation of
furan, thiophene, and pyridine aldimines. Chem. Heterocycl. Comp., 2003,
vol.39, N 1, pp.49-55.
- G. Veinberg, M. Vorona, I. Shestakova, I. Kanepe, E. Lukevics. Design of ß-lactams with
mechanism based nonbacterial activities. Current Medicinal Chemistry,
2003, vol.10, N 17, pp.1741-1757.
- E. Lukevics, P. Arsenyan, O. Pudova. Methods for the synthesis of oligothiophenes.
Heterocycles, 2003, vol.60, N 3, pp.663-687.
- V.Dirnens, V.Klusa, J.Skuyins, S.Svirskis, S.Germane, A.Kemme, E.Lukevics. Synthesis and
pharmacological activity of silyl isoxazolines-2. - Silicon Chemistry, 2003
(publ. 2004), vol. 2, N 1/2, pp. 11-25.
- I.Iovel, L.Golomba, M.Fleischer, J.Popelis, S.Grinberga, E.Lukevics. Hydrosilylation of
(hetero)aromatic aldimines in the presence of Pd(I) complex. - Chem.Heterocycl. Comp.,
2004, vol. 40, N 6, pp. 701-714.
- P.Arsenyan, O.Pudova, J.Popelis, E.Lukevics. Novel radial oligothienylsilanes. - Tetrahedron
Lett., 2004, vol. 45, N 15, pp. 3109-3111.
- E.Lukevics, L.Ignatovich, S.Belyakov. Crystallographic report: 2-furfurylgermatrane. - Appl.
Organomet. Chem., 2004, vol. 18, N 4, p. 203.
- G. Veinberg, I. Shestakova, M. Vorona, I. Kanepe, E. Lukevics. Synthesis of
antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones. -
Bioorg. Med. Chem. Letters, 2004, vol. 14, No 1, 147-150.
- E.Lukevics, L.Ignatovich, T.Shulga, S.Belyakov. 1-[4-(2-Thienyl)phenyl]germatrane. -
Appl. Organomet. Chem., 2005, vol. 19, N 1, pp. 167-168.
- E.Lukevics, L.Ignatovich. Biological activity of organosilicon compounds. - In: Metallotherapeutic
Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine / Eds.
M.Gielen, E.R.T.Tiekink/, 2005, J.Wiley & Sons, Ltd. Chichester, pp. 83-107.
- E.Lukevics, L.Ignatovich. Biological activity of organogermanium compounds. - In: Metallotherapeutic
Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine / Eds.
M.Gielen, E.R.T.Tiekink/, 2005, J.Wiley & Sons, Ltd. Chichester, pp. 279-295.
- Yu.Melnik, M.Vorona, G.Veinberg, J.Popelis, L.Ignatovich, E.Lukevics. Synthesis and
stereoisomerization of 2-(1-alkoxyimino-2,2,2-trifluoroethyl)-5-trimethylsilylfurans. -
Chem. Heterocycl. Comp., 2005, vol. 41, N 6, pp. 718-721.
- L.Ignatovich, J.Popelis, E.Lukevics. Synthesis and NMR spectra of diaryl- and
dihetarylsilacycloalkanes. - In: Organosilicon Chemistry VI / Eds. N.Auner and
J.Weis/, Wiley-VCH Weinheim, 2005, vol. 1, pp. 559-562.
- L.Ignatovich, D.Zarina, I.Shestakova, S.Germane, E.Lukevics. Synthesis and bological
activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes. - In: Organosilicon
Chemistry VI / Eds. N.Auner and J.Weis/, Wiley-VCH Weinheim, 2005, vol. 1, pp.
563-568.
- E.Lukevics, L.Ignatovich, I.Sleiksha, I.Shestakova, I.Domrachova, J.Popelis. Synthesis
and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes. - Appl.
Organomet. Chem., 2005, vol. 19, N 10, pp. 1109-1113.
- S.Belyakov, E.Alksnis, V.Muravenko, I.Turovskis, J.Popelis, E.Lukevics. Crystal
structure and conformation of 8-(2-hydroxyethylamino)- and
8-(pyrrolidin-1-yl)adenosines. - Nucleosides, Nucleotides & Nucleic Acid,
2005, vol. 24, N 8, pp. 1199-1208.
- A. Zablotskaya, I.Segal, S.Belyakov, E.Lukevics. Silyl modification of biologically
active compounds. 11. Synthesis, physico-chemical and biological evaluation of
N-(trialkoxysilylalkyl)tetrahydro(iso,silaiso)quinoline derivatives. Appl. Organomet.
Chem. 2006, vol.20, N 2, 149-159.
- A.Zablotskaya, I.Segal, J.Popelis, E.Lukevics, S.Baluja, I.Shestakova, I.Domracheva.
Silyl modification of biologically active compounds. 12. Silyl group as true incentive to
antitumour and antibacterial action of choline and colamine analogues. - Appl.
Organomet. Chem. 2006, vol. 20, N 11, 721-728.
- E.Lukevics, L.Ignatovich, I.Sleiksha, V.Muravenko, I.Shestakova, S.Belyakov, J.Popelis.
Synthesis, structure and cytotoxic activity of 2-acetyl-5-trimethylsilylthiophene(furan)
and their oximes. - Appl. Organomet. Chem. 2006, vol 20, N 7,
454-458.
- L.Ignatovich, V.Muravenko, S.Grinberga, E.Lukevics. Novel reactions to form an Si-O-Ge
group. - Chem.Heterocycl. Comp., 2006, vol. 42, N 2, 268-271.
- E.Lukevics, I.Shestakova, I.Domrachova, A.Nesterova, Y.Ashaks, D.Zaruma. Synthesis of
complex compounds of methyl derivatives of 8-quinolineselenol with metals and their
cytotoxic activity. - Chem.Heterocycl. Comp., 2006, vol. 42, N 1,
53-59.
- E.Lukevics, L.Ignatovich, I.Sleiksha, V.Romanov, S.Grinberga, J.Popelis, I.Shestakova. A
New method for the synthesis of silicon- and germanium-containing 2-acetylfurans and
2-acetylthiophenes. - Chem.Heterocycl. Comp., 2007, vol. 43, N 2, 143-150.
- V.Dirnens, I.Skrastina, J.Popelis, E.Lukevics. Synthesis of isoxazolinylxanthines. - Chem.Heterocycl.
Comp., 2007, vol. 43, N 2, 193-196.
- E.Lukevics, L.Ignatovich, S.Belyakov. Disordering in the crystal structure of
thienylgermatranes. - Chem.Heterocycl. Comp., 2007, vol. 43, N 2,
243-249.
- E.Lukevics, I.Shestakova, I.Domrachova, E. Yashchenko, D.Zaruma. Y.Ashaks. Cytotoxic
di(8-quinolyl)disulfides. - Chem.Heterocycl. Comp., 2007, vol. 43, N 5, 629-633.
- V.M.Vorona, I.Potorocina, G.Veinberg, I.Shestakova, I.Kanepe, M.Petrova, E. Liepinsh,
E.Lukevics. Synthesis and structural modification of tert-butyl ester of
7a-chloro-2-(N,N-dimethylaminomethylene)-3-methyl-1,1-dioxoceph-3-em carboxylic acid.- Chem.Heterocycl.
Comp., 2007, vol. 43, N 5, 646-652.
- A.Zablotskaya, I.Segal, E.Lukevics, S.Belyakov, H.Spies. Tetrahydroquinoline and
tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set.- Appl.Organomet.Chem.,
2007, vol.21, N 4, 288-293.
- A.Zablotskaya, I.Segal, M. Maiorov, D. Zablotsky, A. Mishnev E.Lukevics, I.Shestakova,
I. Domracheva. Synthesis and characterization of nanoparticles with an iron oxide magnetic
core and a biologically active trialkylsilylated aliphatic alkanolamine shell. J. Magn.
Magn. Mater. 2007, 311, pp. 135-139.
- Zablotskaya A., Segal I., Lukevics E., Maiorov M., Zablotsky D., Blums E., Shestakova
I., Domracheva I. Synyhesis, physico-chemical and biological study of
trialkylsiloxyalkylamine coated iron oxide/oleic acid magnetic nanoparticles for the
treatment of cancer. - Appl. Organomet. Chem. 2008, vol. 22, pp. 82-88.
- E.Lukevics, E.Abele. Four-membered rings with three heteroatoms not including oxygen,
sulfur or nitrogen atom. - In: Comprehensive Heterocyclic Chemistry III., 2008,
2. Four-membered heterocycles together with all fused systems containing a
four-membered heterocyclic ring (Exec. Ed. A. Katritzky, FRS: Eds Ch.A. Ramsden,
E.V.Scriven, R.J.Taylor), pp. 973-989.
- Soualami S., Ignatovich L., Lukevics E.,Ourari A., Jouikov V. Electrochemical oxidation
of benzylgermatranes. - J. Organomet. Chem., 2008, vol.693 (7), pp. 1346-1352.
- Lukevics E., Ignatovich L., Shul'ga T., Belyakov S. Synthesis and crystal
structure of 1-(4-fluorophenyl)- and 1-(4-dimethylamino)phenylgermatranes. - Chem.
Heterocycl.Comp. (Engl.Ed.), 2008, vol. 44 (5), pp. 615-620.
- Abele E., Lukevics E. Synthesis of Heterocycles from Oximes. - In: The Chemistry of
Hydroxylamines, Oximes and Hydroxamic Acids. (Eds. Z.Rapoport, J.F.Liebmann ),
J.Wiley, Chichester, 2009, Part I, pp. 233-302.
- Erchak N., Belyakov S., Kalvinsh I., Pypowski K., Valbahs E., Lukevics E. Two
polymorphic modifications of
1-(N-morpholiniomethyl)spirobi(3-oxo-2,5-dioxa-1-silacyclopentan)ate hydrate. - Chem.Heterocycl.
Comp.(Engl. Ed.), 2009, vol. 45, N 9, pp.1137-1143..
- Zablotskaya A.,Segal I., Lukevics E., Maiorov M., Zablotsky D., Blums E., Shestakova I.,
Domracheva I. Water-soluble magnetic nanoparticleswith biologically active
stabilizers. - J.Magn.Mater., 2009, 321, pp. 1428-1432.
- Ignatovich L., Muravenko V., Shestakova I., Domracheva I, Popelis J., Lukevics E.
Synthesis and Cytotoxic activity of new 2-[(3-aminopropyl)-
dimethylsilyl]-5-triethylsilylfurans. - Appl. Organomet. Chem. 2009, DOI
10.1002, aoc, 1538.
- Vorona M., Veinberg G.,Liepinsh E., Kazoka H., Andrejeva G., Lukevics E. Enzymatic
synthesis of amoxycilloic acids. - Chem.Heterocycl. Comp.(Engl. Ed.), 2009, vol.
45, N 6, pp.782-754.
- Zablotskaya A.,Segal I., Lukevics E. Iron oxide-based magnetic nanostructures bearing
cytotoxic organosilicon molecules for drug delivery and therapy. - Appl. Organomet.
Chem. 2010, vol. 24, N 3, pp. 150-157.
- Ignatovich L., Muravenko V., Shestakova I., Domracheva I, Popelis J., Lukevics E.
Synthesis and Cytotoxic activity of new 2-[(3-aminopropyl)-
dimethylsilyl]-5-triethylsilylfurans. - Appl. Organomet. Chem. 2010, vol. 24,
N 3, pp. 158-161.
- Segal I., Zablotskaya A.,Lukevics E., Maiorov M., Zablotsky D., Blums E., Mishnew A.,
Georgieva R., Shestakova I., Gulbe A. Preparation and cytotoxic properties of
goethite-based nanoparticles covered with decyldimethyl(dimethylaminoethoxy)silane
metoxyde. - Appl. Organomet. Chem. 2010, vol. 24, N 3, pp. 193-197.
- Ignatovich L., Muravenko V., RomanovsV, Sleiksha I., Shestakova I., Domracheva I,
Belyakov S., Popelis J., Lukevics E. Synthesis, structure and cytotoxic activity of new
1-[5-organylsilyl(germyl)-2-furyl(thienyl)]nitroethenes. - Appl. Organomet. Chem.
2010, vol. 24, N 12, pp. 858-864.
- Lukevics E., Abele E., Ignatovich L. Biologically Active Silacyclanes. - Adv.
Heterocycl. Chem., 2010, vol. 99, pp. 107-141.
- Abele E., Lukevics E. Synthesis, structure and reactions of organometallic derivatives
of oximes. - In: The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids.
Eds. by Zvi Rapoport, J.F.Liebman. 2011, Vol.2, Part 1 (Chapter 4), pp. 145-203.
- Katkevics M., Kukosha T., Lukevics E. Heterocycles from hydroxylamines and hydroxamic
acids. - In: The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids.
Eds. by Zvi Rapoport, J.F.Liebman. 2011, Vol.2, Part 1 (Chapter 5), pp. 205-293.
Research Projects:
- E.Lukevics (Head of Project). Silylheterocycles in Organic Chemistry. Latvian Council of Science (1993-1995).
- E.Lukevics (Head of Project). Bifunctional Organosilicon Compounds. Latvian Council
of Science (1993-1995).
- E.Lukevics (Head of Project). Synthesis of Heterocyclic Organosilicon and
Organogermanium Compounds, Investigation of their Physical and Chemical Properties.
Latvian Council of Science (1997-2000 ).
- E.Lukevics (Head of Project). Asymmetric and Catalytic Synthesis of Heteroaromatic
Compounds. Latvian Council of Science (1997-2000 ).
- E.Lukevics (Head of Program). The Development of Modern Methods of Organic Chemistry
Directed towards the Development of Pharmaceutical Industry in Latvia. Latvian Council
of Science (1997-2000 ).
- E.Lukevics (Head of Project). Experimental and Theoretical Aspects of the Catalytical
Synthesis of Heteroaromatic Compounds. Latvian Council of Science (2001 -2004
).
- E.Lukevics (Head of Project). Comparative Study of the Structure and Biological Activity
of Organosilicon and Organogermanium Compounds. Latvian Council of Science (2001
- 2004).
- E.Lukevics (Head of Project). Heterocyclic Derivatives of Tetra- and Hypercoordinated
Germanium and Silicon. Latvian Council of Science (2005 -).
- E.Lukevics ( Programme Director). Development of Organic Synthesis Methods
for Obtaining of Biologically Active Compounds. Latvian Council of Science (2002
-2005 ).
- E.Lukevics ( Programme Director). Development of Heteroatom Chemistry
for Preparation of Biologically Active Compounds. Latvian Council of Science (2006
- 2009 ).
- E.Lukevics (Head of Project). Carbofunctional Silylheterocycles. Latvian
Council of Science (2009 ).
Hobbies:
Opera, Basketball, Mountains.
Last update 16.02.2012