Aija LINE
Aija Line, PhD Latvian Biomedical Research and Study Centre Phone: +371 67808208 |
Born: November 19, 1973, Riga, Latvia
Research area:
Tumour immunology: identification and characterisation of tumour antigens, the role of autoantibody profiles in the diagnosis of cancer and prediction of response to immunotherapy, the role of humoral response in anti-tumour immune response;
pre-mRNA splicing defects in cancer: identification of aberrant splice variants in cancer, studies of their frequency and immunogenicity.
Cancer pharmacogenetics: identification of genetic factors determining patients response to cytarabine, fludarabine and cisplatin-based chemotherapy.
Languages: Latvian (native), English, Russian
Education:
2002: Ph.D, University of Latvia
1997: M.Sc. in molecular biology, University of Latvia, Faculty of Biology
1995: B.Sc. in biology, University of Latvia, Faculty of Biology
Research experience:
2005- present: senior scientist, group leader, Latvian Biomedical Research and Study Centre, Riga, Latvia.
2003 (3 months): visiting research scientist with Prof. RC Rees, Nottingham Trent University, UK. Travel Fellowship from the Royal Society (UK).
2002-2005: research scientist, Biomedical Research and Study Centre, University of Latvia, Riga, Latvia
1999 (4 months): postgraduate exchange student at Nottingham Trent University, UK, supervisor Prof. RC Rees. Travel fellowship from TEMPUS.
1998 (6 months): postgraduate exchange student at Nottingham Trent University, UK, supervisor Prof. RC Rees. Travel fellowship from TEMPUS.
1996 (3 months): postgraduate exchange student at Division of Clinical Virology, Karolinska Institutet, Huddinge University Hospital, Sweden, supervisor: Prof. Matti Sallberg.
1993-2002: research assistant, Biomedical Research and Study Centre, University of Latvia, Riga, Latvia
Honours and Awards:
LOREAL, UNESCO and LZA Fellowship for Women in Science
(Latvia) award, year 2005
University of Latvia, K. Morbergs Fellowship award, year 2004/2005
Latvian Academy of Sciences and Grindeks Ltd Award for Young Researchers, year 2002
Latvian Academy of Sciences, Award for Young Scientists, year 1997.
Memberships:
European Association for Cancer Research (EACR)
European Society for Cancer Immunology and Immunotherapy (ESCII)
Other professional activities:
2008 -
expert for EU FP7 Research for SMEs proposals, Call 2 (FP7-SME-2008-1)
2009- present: editor for Biomarkers in Cancer
2005 - present: editor for Central European Journal of Biology (CEJB).
2003 - present: UNEP/GEF Biosafety Clearing-house expert.
2003 - development of assays for molecular diagnostics of leukaemia, GenEra, Ltd.
Grants held:
2005-2008: Partner of EC 6th FP STREP European network for the identification and validation of antigens and biomarkers in cancer and their application in clinical tumour immunology (ENACT).
2007-2008: Partner of Latvian State Research Program Development of novel drugs: construction, transport forms and mechanisms of action (VPP2), sub-project: Development of novel serological test for the early detection of cancer.
2005-2008: Partner of collaborative project: Genomic Studies of the Latvian Population, Latvian Council of Sciences, sub-project: The role of pharmacogenetics in treatment of cancer.
2005-2008: Latvian Council of Sciences grant No.05.1623: Defects of pre-mRNA splicing in cancer: frequency and immunogenicity.
2004-2008: Latvian Council of Sciences grant No.04.1143: Development of bioinformatic method for identification of cancer-specific alternative splice variants.
2001-2004: Latvian Council of Sciences grant No. 01.0226: Molecular characterisation of tumour antigens in gastric and colon cancer.
Representative publications:
1. Zandberga E, Kozirovskis V and Line A. MicroRNAs as diagnostic, prognostic and predictive biomarkers in lung cancer. - Biomarkers in Cancer (submitted).
2. Kalnina Z, Silina K, Bruvere R, Gabruseva N, Stengrevics A, Barnikol-Watanabe S, Leja M, Line A. Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. - Eur J Hisopathol, 2009, 53 (1): 7-18.
3. Kalnina Z, Silina K and Line A. Autoantibody profiles as biomarkers for response to therapy and early detection of cancer. - Current Cancer Therapy Reviews, 2008, 4 (2):149-156.
4. Kalnina Z, Silina K, Meistere I, Zayakin P, Rivosh A, Abols A, Leja M, Minenkova O, Schadendorf D and Line A. Evaluation of T7 and Lambda phage display systems for survey of autoantibody profiles in cancer patients. - J Immunol Methods, 2008 May 20;334(1-2):37-50.
5. Kalnina Z, Silina K, Zajakin P and Line A. Alterations of pre-mRNA splicing in cancer. - Genes, Chromosomes & Cancer, 2005, 42,(4):342-57.
6. Li G, Miles A, Line A, Rees RC. Identification of tumour antigens by serological analysis of cDNA expression cloning. - Cancer Immunol Immunother, 2004, 53 (3):139-43.
7. Line A, Stengrevics A, Slucka Z, Li G, Jankevics E and Rees RC. Serological Identification and Expression Analysis of Gastric Cancer-associated Genes. - Br J Cancer, 2002, 86 (11): 1824-30.
8. Line A, Slucka Z, Stengrevics A, Silina K, Li G and Rees RC. Characterisation of Tumour-associated Antigens in Colon Cancer. - Cancer Immunol Immunother, 2002, 51: 574-582.
9. Line A, Slucka Z, Stengrevics A, Li G and Rees RC. Altered Splicing Pattern of TACC1 mRNA in Gastric Cancer. - Cancer Genet Cytogenet, 2002, 139 (1): 78-83.
Last update 10.11.2009